Competitive Asymmetric Transfer Hydrogenation as a Method to Determine Structural Effects

Authors

  • O. Matuška University of Chemistry and Technology, Prague
  • R. Hrdličková University of Chemistry and Technology, Prague
  • J. Zápal University of Chemistry and Technology, Prague
  • J. Pecháček University of Chemistry and Technology, Prague
  • M. Kuzma University of Chemistry and Technology, Prague
  • P. Kačer University of Chemistry and Technology, Prague

Keywords:

ruthenium, homogeneous catalysis, competitive asymmetric transfer hydrogenation, imine

Abstract

In last two decades, the asymmetric transfer hydrogenation became widely used for the preparation of enantio­enriched substances, mostly chiral amines and alcohols. The competitive asymmetric transfer hydrogenation provides a feasible method to determine structural effects of the molecule of substrate, affecting their affinity to the active site of the catalyst, as well as the selectivity of the catalyst to the substrate. In this work, the course of the asymmetric transfer hydrogenation of two dihydroisoquinoline substrates was studied, employing Noyori's homogeneous ruthenium complex as the catalyst, both individually and in a competitive arrangement. Finally, differences in the behavior of both substrates were explained based on measured data.

Published

2017-02-15

How to Cite

Matuška, O., Hrdličková, R., Zápal, J., Pecháček, J., Kuzma, M., & Kačer, P. (2017). Competitive Asymmetric Transfer Hydrogenation as a Method to Determine Structural Effects. Chemické Listy, 111(2), 163–166. Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/37

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